N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

Base Information

Chemical Name:N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide
CAS No.:1345879-08-4
Molecular Formula:C₂₆H₃₁NO₅
Molecular Weight:437.536
Hs Code.:

Synonyms:N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

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Chemical Property of N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

Chemical Property:

Purity/Quality:

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Technology Process of N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

There total 12 articles about N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1345879-07-3
4-[2-(1-aminomethylcyclopropylmethoxy)-3,4-dimethoxyphenyl]indan-1-one

: 79-30-1
isobutyryl chloride

: 1345879-08-4
N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 5150-42-5
2,3-dimethoxyphenol

: 1345879-08-4
N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 - 25 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

3.2: 0.5 h / -78 °C

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

5.1: hydrogenchloride; water / methanol / 0.25 h / 50 °C

6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

7.1: tetrabutyl ammonium fluoride / trifluoroacetic acid-d₁ / 16 h / 20 °C

8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

9.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 °C

10.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

10.2: 1 h / 80 °C

11.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; n-butyllithium; sodium azide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid-d₁; N,N-dimethyl-formamide;

Reference yield:

: 1345712-96-0
1-bromo-3,4-dimethoxy-2-methoxymethoxybenzene

: 1345879-08-4
N-{1-[2,3-dimethoxy-6-(1-oxoindan-4-yl)phenoxymethyl]cyclopropylmethyl}isobutyramide

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere

3.1: hydrogenchloride; water / methanol / 0.25 h / 50 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

5.1: tetrabutyl ammonium fluoride / trifluoroacetic acid-d₁ / 16 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 °C

8.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

8.2: 1 h / 80 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; n-butyllithium; sodium azide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid-d₁; N,N-dimethyl-formamide;