Technology Process of 4-[2-(1-aminomethylcyclopropylmethoxy)-3,4-dimethoxyphenyl]indan-1-one
There total 11 articles about 4-[2-(1-aminomethylcyclopropylmethoxy)-3,4-dimethoxyphenyl]indan-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-((1-(azidomethyl)cyclopropyl)methoxy)-3,4-dimethoxyphenyl)-2,3-dihydro-1H-inden-1-one;
With
triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
water;
In
tetrahydrofuran;
at 80 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 - 25 °C
2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
3.2: 0.5 h / -78 °C
4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
5.1: hydrogenchloride; water / methanol / 0.25 h / 50 °C
6.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
7.1: tetrabutyl ammonium fluoride / trifluoroacetic acid-d1 / 16 h / 20 °C
8.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
9.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 °C
10.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
10.2: 1 h / 80 °C
With
hydrogenchloride; N-Bromosuccinimide; n-butyllithium; sodium azide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid-d1; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 4 h / 90 °C / Inert atmosphere
3.1: hydrogenchloride; water / methanol / 0.25 h / 50 °C
4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
5.1: tetrabutyl ammonium fluoride / trifluoroacetic acid-d1 / 16 h / 20 °C
6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
7.1: sodium azide / N,N-dimethyl-formamide / 16 h / 20 °C
8.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C
8.2: 1 h / 80 °C
With
hydrogenchloride; n-butyllithium; sodium azide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; caesium carbonate; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid-d1; N,N-dimethyl-formamide;
