3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester

Base Information

Chemical Name:3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester
CAS No.:133496-54-5
Molecular Formula:C₂₄H₂₈FNO₃
Molecular Weight:397.49
Hs Code.:

Synonyms:3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester

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Chemical Property of 3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester

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Technology Process of 3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester

There total 2 articles about 3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 56346-57-7
(4-fluorophenyl)-piperidin-4-ylmethanone

: 133496-52-3
β-(bromomethyl)-γ-phenylbutyric acid, methyl ester

: 133496-54-5
3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester

Guidance literature:: With sodium carbonate; potassium iodide; In various solvent(s); for 20h; Heating;
DOI:10.1021/jm00111a046

Reference yield:

: 133496-51-2
β-(bromomethyl)-γ-phenylbutyric acid

: 133496-54-5
3-Benzyl-4-[4-(4-fluoro-benzoyl)-piperidin-1-yl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether

2: 70 percent / Na₂CO₃, KI / various solvent(s) / 20 h / Heating

With sodium carbonate; potassium iodide; In diethyl ether;
DOI:10.1021/jm00111a046