(S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide
• CAS No.: 1452792-61-8
• Molecular Formula: C₂₃H₂₂N₂O₂S
• Molecular Weight: 390.506
• Mol file: 1452792-61-8.mol

Synonyms:(S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide

Chemical Property of (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide

There total 4 articles about (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

indole (120-72-9) + N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide (343598-64-1) → (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide (1452792-61-8)

Guidance literature:

With (R_p)-4,12-di(4-(3',5'-bis(trifluoromethyl))-phenyl-3-yl)-[2.2]paracyclophane-hydrogenphosphate; In toluene; at -20 ℃; for 12h; enantioselective reaction; Molecular sieve;

DOI:10.1021/acs.orglett.9b01127

Reference yield: 99.0%

→ (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide (1452792-61-8)

Guidance literature:

With C₄₄H₂₇F₁₂O₄P; In toluene; at -20 ℃; for 20h; Molecular sieve; Inert atmosphere; Schlenk technique; Glovebox;

Reference yield:

indole (120-72-9) + N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide (343598-64-1) → (R)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide + (S)-N-((1H-indol-3-yl)(o-tolyl)methyl)-4-methylbenzenesulfonamide (1452792-61-8)

Guidance literature:

With polystyrene-supported (R)-4-(3,3’-bis(3,5-bis(trifluoromethyl)phenyl)-2,2'-diyl hydrogen phosphate-1,1'-binaphthalen-6-yl)methoxymethyl resin; In dichloromethane; at 20 ℃; for 7h; Overall yield = 63 %; enantioselective reaction;

DOI:10.1002/chem.201303860

upstream raw materials:

indole

N-(2-methylphenyl)methylidene-4-methylbenzenesulfonamide

toluene-4-sulfonamide

2-methylphenyl aldehyde