5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

Base Information

Chemical Name:5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione
CAS No.:853201-57-7
Molecular Formula:C₂₄H₂₉NO₄S
Molecular Weight:427.565
Hs Code.:

Synonyms:5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

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Chemical Property of 5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

Chemical Property:

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Technology Process of 5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

There total 4 articles about 5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 328236-47-1
3,5-dimethyl-4-(3'-isopropyl-4'-O-methoxymethylbenzyl)phenol

: 853201-57-7
5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

2.1: LiCl; (Ph₃P)2PdCl₂ / dimethylformamide / 1 h / 60 °C

3.1: ozone / CH₂Cl₂ / -78 °C

3.2: 54 percent / triphenylphosphine / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 82 percent / piperidine / ethanol / 10 h / Heating

5.1: 92 percent / NaBH₄; NaOH; CoCl₂-dimethylglyoxime complex / dimethylformamide; ethanol; H₂O / 3 h / 35 °C

With piperidine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; sodium tetrahydroborate; dichlorobis(dimethylgloximato)cobalt(IV); potassium carbonate; ozone; lithium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Stille coupling;
DOI:10.1016/j.bmc.2005.03.040

Reference yield:

: 848442-44-4
trifluoromethanesulfonic acid 4-(3-isopropyl-4-methoxymethoxybenzyl)-3,5-dimethylphenyl ester

: 853201-57-7
5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: LiCl; (Ph₃P)2PdCl₂ / dimethylformamide / 1 h / 60 °C

2.1: ozone / CH₂Cl₂ / -78 °C

2.2: 54 percent / triphenylphosphine / CH₂Cl₂ / 0.5 h / 20 °C

3.1: 82 percent / piperidine / ethanol / 10 h / Heating

4.1: 92 percent / NaBH₄; NaOH; CoCl₂-dimethylglyoxime complex / dimethylformamide; ethanol; H₂O / 3 h / 35 °C

With piperidine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; sodium tetrahydroborate; dichlorobis(dimethylgloximato)cobalt(IV); ozone; lithium chloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1.1: Stille coupling;
DOI:10.1016/j.bmc.2005.03.040

Reference yield:

: 853201-45-3
4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzaldehyde

: 853201-57-7
5-(4-(3-isopropyl-4-(methoxymethoxy)benzyl)-3,5-dimethylbenzyl)thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / piperidine / ethanol / 10 h / Heating

2: 92 percent / NaBH₄; NaOH; CoCl₂-dimethylglyoxime complex / dimethylformamide; ethanol; H₂O / 3 h / 35 °C

With piperidine; sodium hydroxide; sodium tetrahydroborate; dichlorobis(dimethylgloximato)cobalt(IV); In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.03.040