5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione

Base Information

• Chemical Name: 5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione
• CAS No.: 474901-41-2
• Molecular Formula: C₁₂H₁₀F₂N₂O₄S
• Molecular Weight: 316.285
• Mol file: 474901-41-2.mol

Synonyms:5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property of 5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione

There total 1 articles about 5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione triethylammonium salt → 5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione (474901-41-2)

Guidance literature:

With hydrogenchloride; In acetonitrile; for 12h; Heating;

DOI:10.1002/1099-0690(200205)2002:10<1619::AID-EJOC1619>3.0.CO;2-8

Reference yield: 82.0%

5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione (474901-41-2) → 5-(benzylsulfonyl)-2,4-dichloro-6-(difluoromethyl)pyrimidine (474901-50-3)

Guidance literature:

With phosphorus pentachloride; In benzene; for 12h; Heating;

DOI:10.1002/1099-0690(200205)2002:10<1619::AID-EJOC1619>3.0.CO;2-8

Reference yield:

5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione (474901-41-2) + methyl iodide (74-88-4) → potassium; 6-difluoromethyl-3-methyl-2-oxo-5-phenylmethanesulfonyl-2,3-dihydro-pyrimidin-4-olate

Guidance literature:

5-(benzylsulfonyl)-6-(difluoromethyl)pyrimidine-2,4(1H,3H)-dione; With potassium hydroxide; In methanol; acetonitrile; at 20 ℃;

methyl iodide; In methanol; acetonitrile; at 20 ℃; for 24h; Further stages.;

DOI:10.1002/1099-0690(200205)2002:10<1619::AID-EJOC1619>3.0.CO;2-8

Downstream raw materials:

5-(benzylsulfonyl)-2,4-dichloro-6-(difluoromethyl)pyrimidine

5-(benzylsulfonyl)-2,4-bis(dimethylamino)-6-(difluoromethyl)pyrimidine

C₂₀H₂₄F₂N₄O₄S