N₄-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine

Base Information

• Chemical Name: N₄-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine
• CAS No.: 1354627-40-9
• Molecular Formula: C₂₁H₂₄Cl₂N₈OSi
• Molecular Weight: 503.466

Synonyms:N₄-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine

Chemical Property of N₄-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine

Chemical Property:

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Technology Process of N₄-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine

There total 6 articles about N₄-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-diaminopyrimidine (2434-56-2) + 8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine (1354627-20-5) → N4-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine (1354627-40-9)

Guidance literature:

4,6-diaminopyrimidine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

With water; In N,N-dimethyl-formamide; mineral oil; Cooling;

Reference yield:

6-bromo-8-(2,6-dichlorophenyl)-9H-purine (1227958-56-6) → N4-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine (1354627-40-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2.1: Oxone / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 - 20 °C

3.2: 0.5 h / 0 - 20 °C

3.3: Cooling

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

4.2: 0.5 h / 0 - 20 °C

4.3: Cooling

With Oxone; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

Reference yield:

2,6-dichlorobenzoic acid (50-30-6) → N4-(8-(2,6-dichlorophenyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purin-6-yl)pyrimidine-4,6-diamine (1354627-40-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: polyphosphoric acid / 4 h / 190 °C

1.2: 20 °C / pH 7 - 8 / Cooling with ice

2.1: phosphorus(V) oxybromide / acetonitrile / 0.67 h / 150 °C

3.1: N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4.1: Oxone / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.5 h / 0 - 20 °C

5.2: 0.5 h / 0 - 20 °C

5.3: Cooling

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 20 °C

6.2: 0.5 h / 0 - 20 °C

6.3: Cooling

With Oxone; sodium hydride; phosphorus(V) oxybromide; In N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

2,6-dichlorobenzoic acid

4,6-diaminopyrimidine

8-(2,6-dichlorophenyl)-6-(methylsulfonyl)-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-purine

8-(2,6-dichlorophenyl)-9H-purin-6-ol

Downstream raw materials:

N₄-(8-(2,6-dichlorophenyl)-9H-purin-6-yl)pyrimidine-4,6-diamine

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