(rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

Base Information

Chemical Name:(rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile
CAS No.:1161921-50-1
Molecular Formula:C₂₂H₁₈F₃N₃O₄S
Molecular Weight:477.464
Hs Code.:

Synonyms:(rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

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Chemical Property of (rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

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Technology Process of (rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

There total 5 articles about (rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1161921-93-2
4-formyl-3-(methylsulfonyl)benzonitrile

: 13114-87-9
N-(3-trifluoromethylphenyl)urea

: 123-54-6,81235-32-7
acetylacetone

: 1161921-50-1
(rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

Guidance literature:: With triethyl phosphate; phosphorus pentoxide; In tert-butyl methyl ether; Inert atmosphere; Reflux;

Reference yield:

: 170572-49-3
2-fluoro-4-cyanotoluene

: 1161921-50-1
(rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 20 - 175 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 10 - 20 °C

3: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

4: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

5: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / Inert atmosphere; Reflux

With sodium periodate; triethyl phosphate; phosphorus pentoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 4-methyl-3-(methylsulfanyl)benzonitrile

: 1161921-50-1
(rac)-4-{5-Acetyl-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 10 - 20 °C

2: N,N-dimethyl-formamide / 7 h / 140 °C / Inert atmosphere

3: sodium periodate / water; tetrahydrofuran / 1 h / 20 °C

4: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / Inert atmosphere; Reflux

With sodium periodate; triethyl phosphate; phosphorus pentoxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;