tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

Base Information

Chemical Name:tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate
CAS No.:1419874-06-8
Molecular Formula:C₁₇H₂₂N₄O₄S
Molecular Weight:378.452
Hs Code.:

Synonyms:tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

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Chemical Property of tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

Chemical Property:

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Technology Process of tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

There total 3 articles about tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1419874-05-7
(S)-3-trimethylsiloxy-4-[(1-phenyltetrazole-5-yl)sulfanyl]butyronitrile

: 1419874-06-8
tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

Guidance literature:: (S)-3-trimethylsiloxy-4-[(1-phenyltetrazole-5-yl)sulfanyl]butyronitrile; With methanesulfonic acid; zinc; In tetrahydrofuran; Inert atmosphere; Reflux;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at 50 - 60 ℃; Time; Temperature;

Reference yield:

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 1419874-06-8
tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 90 °C

2.1: triethylamine; dmap / dichloromethane / 0 °C

2.2: 0 - 25 °C

3.1: zinc; methanesulfonic acid / tetrahydrofuran / Inert atmosphere; Reflux

3.2: 50 - 60 °C

With dmap; methanesulfonic acid; triethylamine; sodium iodide; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1419874-04-6
(S)-3-hydroxy-4-[(1-phenyltetrazole-5-yl)sulfanyl]butyronitrile

: 1419874-06-8
tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; dmap / dichloromethane / 0 °C

1.2: 0 - 25 °C

2.1: zinc; methanesulfonic acid / tetrahydrofuran / Inert atmosphere; Reflux

2.2: 50 - 60 °C

With dmap; methanesulfonic acid; triethylamine; zinc; In tetrahydrofuran; dichloromethane;