[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

Base Information

• Chemical Name: [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester
• CAS No.: 380460-39-9
• Molecular Formula: C₂₀H₂₈N₄O₄S
• Molecular Weight: 420.533

Synonyms:[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

Chemical Property of [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

There total 11 articles about [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-mercapto-1-phenyl-1H-tetrazole sodium salt (15052-19-4) + (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester (154026-94-5,521973-99-9,521974-00-5,521974-01-6) → [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester (380460-39-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 80 - 100 ℃; for 10.5h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

tert-butyl (3R,5S)-3,5-dihydroxy-6-(1-phenyltetrazole-5-sulfanyl)hexanoate (1419874-07-9) + 2,2-dimethoxy-propane (77-76-9) → [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester (380460-39-9)

Guidance literature:

With methanesulfonic acid; In acetone; at 20 ℃; for 3h; Concentration;

Reference yield:

1-Phenyl-1H-tetrazole-5-thiol (86-93-1) + (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester (154026-94-5,521973-99-9,521974-00-5,521974-01-6) → [(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester (380460-39-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 20h;

upstream raw materials:

5-mercapto-1-phenyl-1H-tetrazole sodium salt

(4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid,1,1-dimethylethyl ester

(S)-3-trimethylsiloxy-4-[(1-phenyltetrazole-5-yl)sulfanyl]butyronitrile

tert-butyl (5S)-5-hydroxy-3-oxo-6-(1-phenyltetrazole-5-sulfanyl) hexanoate

Downstream raw materials:

[(4R,6S)-2,2-dimethyl-6-(1-phenyl-1H-tetrazole-5-sulfonylmethyl)[1,3]dioxan-4-yl]acetic acid tert-butyl ester

2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester

rosuvastatin tert-butyl ester

rosuvastatin

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