3-(4-Chlorophenyl)-3-hydroxypropanoic acid

Base Information

Chemical Name:3-(4-Chlorophenyl)-3-hydroxypropanoic acid
CAS No.:25209-46-5
Molecular Formula:C₉H₉ClO₃
Molecular Weight:200.622
Hs Code.:
European Community (EC) Number:845-004-0
UNII:J97448L6PV

Synonyms:3-(4-chlorophenyl)-3-hydroxypropanoic acid;25209-46-5;Benzenepropanoic acid, 4-chloro-b-hydroxy-;J97448L6PV;Pitolisant metabolite BP1.10749;BP1.10749;UNII-J97448L6PV;SCHEMBL1503961;AKOS011682733;4-Chloro-beta-hydroxybenzenepropanoic acid;3-(4-chlorophenyl)-3-hydroxypropanoicacid;CS-0221826;EN300-100179;F88348;4-CHLORO-.BETA.-HYDROXYBENZENEPROPANOIC ACID;Z982132070

Suppliers and Price of 3-(4-Chlorophenyl)-3-hydroxypropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-(4-chlorophenyl)-3-hydroxypropanoicAcid
100mg
$ 285.00

TRC
3-(4-chlorophenyl)-3-hydroxypropanoicAcid
10mg
$ 45.00

AK Scientific
3-(4-Chlorophenyl)-3-hydroxypropanoicacid
250mg
$ 399.00

Total 5 raw suppliers

Chemical Property of 3-(4-Chlorophenyl)-3-hydroxypropanoic acid

Chemical Property:

Melting Point:92-94 °C
Boiling Point:367.6±32.0 °C(Predicted)
Density:1.397±0.06 g/cm3(Predicted)
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:200.0240218
Heavy Atom Count:13
Complexity:176

Purity/Quality:

99% ^*data from raw suppliers

3-(4-chlorophenyl)-3-hydroxypropanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(CC(=O)O)O)Cl

Technology Process of 3-(4-Chlorophenyl)-3-hydroxypropanoic acid

There total 6 articles about 3-(4-Chlorophenyl)-3-hydroxypropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: methyl 3-hydroxy-3-(p-chlorophenyl)propionate

: 25209-46-5
3-(4-chlorophenyl)-3-hydroxypropanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In methanol; water; at -78 ℃; for 6h;

Reference yield: 69.0%

: 104-88-1
4-chlorobenzaldehyde

: 64-19-7,77671-22-8
acetic acid

: 25209-46-5
3-(4-chlorophenyl)-3-hydroxypropanoic acid

Guidance literature:: acetic acid; With n-butyllithium; 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane; In tetrahydrofuran; at -78 - 0 ℃;

4-chlorobenzaldehyde; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1002/ejoc.200390195

Reference yield:

: 84466-38-6
(RS)-3-(4-chlorophenyl)-3-hydroxypropionitrile

: 25209-46-5
3-(4-chlorophenyl)-3-hydroxypropanoic acid

: 99839-00-6
3-(4-chlorophenyl)-3-hydroxypropanamide

Guidance literature:: With potassium phosphate buffer; lyophilized Zea mays nitrilase ZmNIT₂ EC 3.5.5.1; In water; at 30 ℃; for 14h; pH=7.15; Title compound not separated from byproducts;
DOI:10.1016/j.tet.2006.04.069