7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

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Chemical Name:7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
CAS No.:1416970-61-0
Molecular Formula:C₃₂H₃₅FN₄O₂
Molecular Weight:526.654
Hs Code.:

Synonyms:7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

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Technology Process of 7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

There total 5 articles about 7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-(1-(3-fluorobenzyl)-1H-indol-4-yl)piperazine hydrochloride

: 129722-34-5
7-(4-bromobutoxy)-3,4-dihydro-2(1H)-quinolinone

: 1416970-61-0
7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: With triethylamine; potassium iodide; In acetonitrile; for 8h; Reflux;
DOI:10.1016/j.physbeh.2013.05.042

Reference yield:

: 920285-05-8
4-[1-(3-fluoro-benzyl)-1H-indol-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

: 1416970-61-0
7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

2: potassium iodide; triethylamine / acetonitrile / 8 h / Reflux

With hydrogenchloride; triethylamine; potassium iodide; In 1,4-dioxane; acetonitrile;
DOI:10.1016/j.physbeh.2013.05.042

Reference yield:

: 252978-89-5
4-(1H-indol-4-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1416970-61-0
7-[4-[4-[1-[(3-fluorophenyl)methyl]indol-4-yl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; 18-crown-6 ether / tetrahydrofuran / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3.1: potassium iodide; triethylamine / acetonitrile / 8 h / Reflux

With hydrogenchloride; 18-crown-6 ether; potassium tert-butylate; triethylamine; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile;
DOI:10.1016/j.physbeh.2013.05.042