Pyrazolo[4,3-c]pyrazole-3-carboxylic acid, 1,4-dihydro-6-nitro- (9CI)

Base Information

• Chemical Name: Pyrazolo[4,3-c]pyrazole-3-carboxylic acid, 1,4-dihydro-6-nitro- (9CI)
• CAS No.: 161155-32-4
• Molecular Formula: C₅H₃N₅O₄
• Molecular Weight: 197.11
• Mol file: 161155-32-4.mol

Synonyms:Pyrazolo[4,3-c]pyrazole-3-carboxylic acid, 1,4-dihydro-6-nitro- (9CI)

Chemical Property of Pyrazolo[4,3-c]pyrazole-3-carboxylic acid, 1,4-dihydro-6-nitro- (9CI)

Chemical Property:

• PSA: 140.48000
• LogP: 0.41560

Purity/Quality:

6-Nitro-2,4-dihydropyrazolo[4,3-c]pyrazole-3-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazolo[4,3-c]pyrazole-3-carboxylic acid, 1,4-dihydro-6-nitro- (9CI)

There total 7 articles about Pyrazolo[4,3-c]pyrazole-3-carboxylic acid, 1,4-dihydro-6-nitro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

1H,4H-3-methyl-6-nitropyrazolo<4,3-c>pyrazole (161155-31-3) → 1H,4H-3-carboxy-6-nitropyrazolo<4,3-c>pyrazole (161155-32-4)

Guidance literature:

With sodium dichromate; sulfuric acid; at 20 - 30 ℃; for 1.5h;

DOI:10.1007/BF00704200

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 1H,4H-3-carboxy-6-nitropyrazolo<4,3-c>pyrazole (161155-32-4)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium nitrite; hydrogenchloride / water

2: hydrazine

3: hydrazine / ethanol

4: sodium nitrite; acetic acid / water / 5 h / 0 - 5 °C

5: acetic acid / ethyl acetate

6: nitric acid; trifluoroacetic acid

7: sulfuric acid; sodium dichromate

With hydrogenchloride; sodium dichromate; sulfuric acid; nitric acid; acetic acid; trifluoroacetic acid; hydrazine; sodium nitrite; In ethanol; water; ethyl acetate;

DOI:10.1002/asia.201402538

Reference yield:

Isonitrosoacetylacetone (29917-12-2) → 1H,4H-3-carboxy-6-nitropyrazolo<4,3-c>pyrazole (161155-32-4)

Guidance literature:

Multi-step reaction with 6 steps

1: hydrazine

2: hydrazine / ethanol

3: sodium nitrite; acetic acid / water / 5 h / 0 - 5 °C

4: acetic acid / ethyl acetate

5: nitric acid; trifluoroacetic acid

6: sulfuric acid; sodium dichromate

With sodium dichromate; sulfuric acid; nitric acid; acetic acid; trifluoroacetic acid; hydrazine; sodium nitrite; In ethanol; water; ethyl acetate;

DOI:10.1002/asia.201402538

upstream raw materials:

1H,4H-3-methyl-6-nitropyrazolo<4,3-c>pyrazole

3-methyl-1,4-dihydro-pyrazolo[4,3-c]pyrazole

acetylacetone

Isonitrosoacetylacetone

Downstream raw materials:

1H,4H-3-nitropyrazolo<4,3-c>pyrazole