<1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol

Base Information

Chemical Name:<1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol
CAS No.:131101-21-8
Molecular Formula:C₁₆H₁₇Cl₂FN₆O₂
Molecular Weight:415.254
Hs Code.:

Synonyms:<1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol

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Chemical Property of <1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol

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Technology Process of <1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol

There total 2 articles about <1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2028-74-2
p-chlorobenzenediazonium chloride

: 131101-19-4
<1R-(1α,2β,3α,5β)>-3-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-fluoro-5-hydroxycyclopentanemethanol

: 131101-21-8
<1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol

Guidance literature:: With sodium acetate; acetic acid; In water; Ambient temperature;
DOI:10.1021/jm00107a006

Reference yield:

: 110567-26-5
<1S-(1α,2β,3α,4β)>-2-fluoro-4-(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-cyclopentanamine

: 131101-21-8
<1R-(1α,2β,3α,5β)>-3-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-fluoro-5-hydroxycyclopentanemethanol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / H₂, 1 N HCl / 10percent Pd/C / methanol / 3 h / Ambient temperature

2: 80 percent / Et₃N / ethanol / 48 h / Heating

3: 77 percent / NaOAc, AcOH / H₂O / Ambient temperature

With hydrogenchloride; hydrogen; sodium acetate; acetic acid; triethylamine; palladium on activated charcoal; In methanol; ethanol; water;
DOI:10.1021/jm00107a006