methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate
CAS No.:1268867-16-8
Molecular Formula:C₂₃H₂₄FN₃O₂
Molecular Weight:393.461
Hs Code.:

Synonyms:methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

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Chemical Property of methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

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Technology Process of methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

There total 5 articles about methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1193-12-0
3,3-dimethylpiperidine

: 1268867-03-3
methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

: 1268867-16-8
methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: In dimethyl sulfoxide; at 100 ℃; Sealed tube;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268867-16-8
methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent)

3.2: pH 7

4.1: dimethyl sulfoxide / 100 °C / Sealed tube

With hydrogen; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1268867-16-8
methyl 3-(3,3-dimethylpiperidin-1-yl)-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C

4.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent)

4.2: pH 7

5.1: dimethyl sulfoxide / 100 °C / Sealed tube

With thionyl chloride; hydrogen; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;