2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester
CAS No.:862711-60-2
Molecular Formula:C₂₁H₃₁NO₆
Molecular Weight:393.48
Hs Code.:

2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-<i>tert</i>-butyl ester

Synonyms:2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Chemical Property of 2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

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Technology Process of 2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

There total 5 articles about 2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 862711-24-8
N-tert-butoxycarbonyl-2-allylpipecolic acid benzyl ester

: 862711-60-2
2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: With 4-methylmorpholine N-oxide; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/jo050529k

Reference yield:

: 862711-13-5
N-tert-butoxycarbonyl-2-allyl-DL-pipecolic acid

: 862711-60-2
2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / 3 h / Heating

2: 99 percent / N-methylmorpholine oxide / OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol

With 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol; benzene;
DOI:10.1021/jo050529k

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 862711-60-2
2-(2,3-dihydroxy-propyl)-piperidine-1,2-dicarboxylic acid 2-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / tetramethylammonium hydroxide pentahydrate / acetonitrile / 48 h / 20 °C

2.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 1 h

2.2: 90 percent / tetrahydrofuran; hexane / 24 h

3.1: 100 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene / 3 h / Heating

4.1: 99 percent / N-methylmorpholine oxide / OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol

With n-butyllithium; tetramethyl ammoniumhydroxide; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; osmium(VIII) oxide; In tetrahydrofuran; hexane; water; acetonitrile; tert-butyl alcohol; benzene;
DOI:10.1021/jo050529k