2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

Base Information

Chemical Name:2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide
CAS No.:1191446-85-1
Molecular Formula:C₅₅H₈₄BrNO₅Si
Molecular Weight:947.265
Hs Code.:

2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

Synonyms:2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

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Chemical Property of 2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

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Technology Process of 2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

There total 1 articles about 2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1191446-84-0
2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl alcohol

: C₅₀H₇₆BrNO₄Si

: 1191446-85-1
2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 ℃; for 3.5h; Inert atmosphere;
DOI:10.1139/V09-083

Reference yield:

: 1191446-85-1
2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

: 1191446-62-4
2-{3'-amino-5'-[13''-(3''',17'''β-dihydroxyestra-1''',3''',5'''(10''')-trien-16'''β-yl)tridecyl]phenyl}ethyl bromide

: 1191447-05-8
2-{3'-amino-5'-[13''-(3''',17'''β-dihydroxyestra-1''',3''',5'''(10''')-trien-16'''β-yl)tridecyl]phenyl}ethyl bromide hydrochloride

Guidance literature:: 2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide; With hydrogenchloride; methanol; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 16h;
DOI:10.1139/V09-083

Reference yield:

: 1191446-85-1
2-{3'-(tert-butoxycarbonylamino)-5'-[13''-(3'''-(tert-butyldimethylsilyloxy)-17'''β-(tetrahydro-2H-pyran-2-yl-oxy)-estra-1''',3''',5'''(10''')-trien-16β-yl)tridec-1-ynyl]phenyl}ethyl bromide

: C₃₉H₅₄BrNO₂

: C₃₉H₅₄BrNO₂*ClH

Guidance literature:: With hydrogenchloride; methanol; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1139/V09-083