sunitinib malate

Base Information

• Chemical Name: sunitinib malate
• CAS No.: 499220-14-3
• Molecular Formula: C₄H₆O₅*C₂₂H₂₇FN₄O₂
• Molecular Weight: 532.569

Synonyms:sunitinib malate

Chemical Property of sunitinib malate

Chemical Property:

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Technology Process of sunitinib malate

There total 1 articles about sunitinib malate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

sunitinib (342641-94-5,326914-13-0) + (S)-Malic acid (97-67-6,78644-42-5) → sunitinib malate (499220-14-3)

Guidance literature:

In methanol; at 50 ℃; Product distribution / selectivity;

Reference yield:

sunitinib malate (499220-14-3) → 5-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid(2-diethylamino-ethyl)-amide (326914-13-0) + sunitinib (557795-19-4,326914-13-0)

Guidance literature:

With sodium hydroxide; In water; Darkness;

DOI:10.1021/acs.jmedchem.8b00812

upstream raw materials:

sunitinib

(S)-Malic acid

Downstream raw materials:

5-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid(2-diethylamino-ethyl)-amide

sunitinib

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