(R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate
CAS No.:911826-16-9
Molecular Formula:C₂₄H₂₆F₂N₆O₃
Molecular Weight:484.506
Hs Code.:

Synonyms:(R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

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Chemical Property of (R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

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Technology Process of (R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

There total 6 articles about (R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 911826-15-8
(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

: 911826-16-9
(R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

Guidance literature:: With sodium dithionite; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; at 20 ℃; for 0.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 911826-16-9
(R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / dichloromethane / 15 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 15 h

4: potassium carbonate / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

5: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran; methanol / 0.5 h / 20 °C

With dmap; sodium dithionite; water; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 364-78-3
2-nitro-4-fluoroaniline

: 911826-16-9
(R)-tert-butyl 2-(5-amino-4-(8-fluorochroman-4-ylamino)pyrimidin-2-ylamino)-4-fluorophenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / dichloromethane / 15 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 15 h

4: potassium carbonate / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

5: sodium dithionite; water; sodium hydrogencarbonate / tetrahydrofuran; methanol / 0.5 h / 20 °C

With dmap; sodium dithionite; water; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; acetonitrile;