(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

Base Information

Chemical Name:(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate
CAS No.:911826-15-8
Molecular Formula:C₂₄H₂₄F₂N₆O₅
Molecular Weight:514.489
Hs Code.:

Synonyms:(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

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Chemical Property of (R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

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Technology Process of (R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

There total 5 articles about (R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 911826-14-7
tert-butyl 4-fluoro-2-(5-nitro-4-thiocyanatopyrimidin-2-ylamino)phenylcarbamate

: 730980-49-1
(R)-8-fluorochroman-4-amine hydrochloride

: 911826-15-8
(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 15h; Product distribution / selectivity;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 911826-15-8
(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / dichloromethane / 15 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 15 h

4: potassium carbonate / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

With dmap; potassium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 364-78-3
2-nitro-4-fluoroaniline

: 911826-15-8
(R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap / dichloromethane / 15 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 15 h

4: potassium carbonate / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

With dmap; potassium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;