17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

Base Information

Chemical Name:17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan
CAS No.:1137990-21-6
Molecular Formula:C₃₀H₃₄N₂O₄
Molecular Weight:486.611
Hs Code.:

Synonyms:17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

Suppliers and Price of 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

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Technology Process of 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

There total 1 articles about 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 102-92-1,17082-09-6
Cinnamoyl chloride

: naltrexamine 3-O-methyl ether

: 1137990-21-6
17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 1h;
DOI:10.1021/jm8015552

Reference yield: 83.0%

: 1137990-21-6
17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

: 106-95-6
allyl bromide

: 1137990-49-8
14β-allyloxy-17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-6β-(cinnamoylamino)morphinan

Guidance literature:: 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

allyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1021/jm8015552

Reference yield: 65.0%

: 1137990-21-6
17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan

: 100-39-0
benzyl bromide

: 1137990-47-6
14β-benzyloxy-17-cyclopropylmethyl-4,5α-epoxy-3-methoxy-6β-(cinnamoylamino)morphinan

Guidance literature:: 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-(cinnamoylamino)morphinan; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1021/jm8015552