(2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

Base Information

Chemical Name:(2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone
CAS No.:107148-99-2
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:(2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

Chemical Property:

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Technology Process of (2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

There total 1 articles about (2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107148-95-8,107148-96-9,107148-97-0,107148-98-1
(2RS,3S)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

: 106-95-6
allyl bromide

: 107148-99-2
(2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) THF, 45 deg C, 4 h, 2.) THF, from 0 deg C to RT, 14 h;
DOI:10.1021/jo00383a026

Reference yield: 95.0%

: 107148-99-2
(2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

: 107149-01-9
(2S,3S)-(+)-2-methyl-3-cyano-3-(3,4,5-trimethoxyphenyl)hex-5-enol

Guidance literature:: With ammonia; trimethylaluminum; In 1,1,2-trichloroethane; toluene; for 60h; Heating;
DOI:10.1021/jo00383a026

Reference yield:

: 107148-99-2
(2S,3S)-(-)-2-(2-propenyl)-2-(3,4,5-trimethoxyphenyl)-3-methylbutyrolactone

: 36622-40-9
(-)-Gallopamil

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / NH₃, AlMe₃ / 1,1,2-trichloro-ethane; toluene / 60 h / Heating

2: 97 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: 94 percent / NaBH₄, tert-butyl alcohol / CH₂Cl₂ / 70 h / Heating

4: 1.) borane, 2-methyl-2-butene, 2.) 30percent aq. H₂O₂ / 1.) THF, 0 deg C, 1 h, 2.) THF, H₂O, 0 deg C, 30 min

5: Et₃N / CH₂Cl₂ / 24 h / 0 °C

6: Et₃N / tetrahydrofuran / 48 h / 80 °C

With sodium tetrahydroborate; 2-methyl-but-2-ene; borane; ammonia; dihydrogen peroxide; trimethylaluminum; triethylamine; tert-butyl alcohol; In tetrahydrofuran; dichloromethane; 1,1,2-trichloroethane; toluene;
DOI:10.1021/jo00383a026