(S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

Base Information

• Chemical Name: (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)
• CAS No.: 161005-84-1
• Molecular Formula: C19H24NO5PS
• Molecular Weight: 409.443
• Hs Code.: 2934999090
• Mol file: 161005-84-1.mol

Synonyms:(S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

Chemical Property of (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

Chemical Property:

• PSA: 128.28000
• LogP: 4.04450
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(3S)-N,N-Dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propanamine phosphate (1:1) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1)

There total 4 articles about (S)-N,N-DIMETHYL-[3-(2-THIENYL)-3-(1-NAPHTHYLOXY)PROPYL]AMINE--PHOSPHORIC ACID (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Fluoronaphthalene (321-38-0) + (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol (132335-44-5) → (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt (161005-84-1,164015-32-1)

Guidance literature:

1-Fluoronaphthalene; (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol; With potassium hydroxide; In diethylene glycol dimethyl ether; at 120 ℃; for 3 - 6h;

With phosphoric acid; In water; ethyl acetate; for 1.08333 - 1.25h;

Reference yield:

1-Fluoronaphthalene (321-38-0) + Potassium benzoate (582-25-2) → (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt (161005-84-1,164015-32-1)

Guidance literature:

With phosphoric acid; In mineral oil,with; hexane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

1-Fluoronaphthalene (321-38-0) + Potassium benzoate (582-25-2) + (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol (132335-44-5) → (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt (161005-84-1,164015-32-1)

Guidance literature:

With phosphoric acid; In hexane; water; dimethyl sulfoxide; mineral oil;

upstream raw materials:

1-Fluoronaphthalene

Potassium benzoate

(S)-3-dimethylamino-1-(2-thienyl)propan-1-ol

Downstream raw materials:

duloxetine hydrochloride

(S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine