Duloxetine IMpurity A

Base Information

Chemical Name:Duloxetine IMpurity A
CAS No.:947686-09-1
Molecular Formula:C25H23NO3S
Molecular Weight:417.529
Hs Code.:
Mol file:947686-09-1.mol

Synonyms:Duloxetine IMpurity A;Duloxetine Phenyl CarbaMate;N-Methyl-N-[(3S)-3-(1-naphthalenyloxy)-3-(2-thienyl)propyl]carbaMic Acid Phenyl Ester

Suppliers and Price of Duloxetine IMpurity A

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DuloxetinePhenylCarbamate(>85%)
100mg
$ 1455.00

Total 17 raw suppliers

Chemical Property of Duloxetine IMpurity A

Chemical Property:

Boiling Point:589.9±50.0 °C(Predicted)
PKA:-1.75±0.70(Predicted)
PSA：67.01000
Density:1.237±0.06 g/cm3(Predicted)
LogP:6.54230
Storage Temp.:Refrigerator, under inert atmosphere
Solubility.:Dichloromethane (Slightly), DMSO (Slightly)

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

DuloxetinePhenylCarbamate(>85%) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Duloxetine Phenyl Carbamate is a degradation product of Duloxetine (D721000). Duloxetine impurity A.

Technology Process of Duloxetine IMpurity A

There total 10 articles about Duloxetine IMpurity A which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 321-38-0
1-Fluoronaphthalene

: (S)-3-(N-methyl-N-phenoxycarbonylamino)-1-(2-thienyl)-1-propanol

: 947686-09-1
(S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine

Guidance literature:: (S)-3-(N-methyl-N-phenoxycarbonylamino)-1-(2-thienyl)-1-propanol; With sodium hydroxide; In dimethyl sulfoxide; at 20 - 30 ℃; Inert atmosphere;

1-Fluoronaphthalene; at 60 - 65 ℃;

Reference yield: 75.6%

: 132335-46-7
N-methyl-(S)-duloxetine

: 1885-14-9
phenyl chloroformate

: 947686-09-1
(S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine

Guidance literature:: N-methyl-(S)-duloxetine; With N-ethyl-N,N-diisopropylamine; In toluene; at 45 ℃; for 0.166667h;

phenyl chloroformate; at 55 ℃; for 2h;
DOI:10.1016/j.bioorg.2016.02.002

Reference yield:

: 161005-84-1,164015-32-1
(S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt

: 1885-14-9
phenyl chloroformate

: 947686-09-1
(S)-N-methyl-N-phenoxycarbonyl-3-(1-naphthyloxy)-3-(2-thienyl)-1-propylamine

Guidance literature:: (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine, phosphoric acid salt; With ammonia; In water; toluene; for 0.166667h;

phenyl chloroformate; With triethylamine; In toluene; at 50 ℃; for 1.75h;