4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

Base Information

Chemical Name:4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione
CAS No.:119452-13-0
Molecular Formula:C₁₄H₁₃N₃O₂S
Molecular Weight:287.342
Hs Code.:

Synonyms:4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

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Chemical Property of 4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

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Technology Process of 4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

There total 4 articles about 4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 119452-03-8
6-Methyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

: 74-88-4
methyl iodide

: 119452-13-0
4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

Guidance literature:: With potassium fluoride on basic alumina; In acetonitrile; for 2h; Ambient temperature;
DOI:10.1248/cpb.36.2902

Reference yield:

: 115106-41-7
4-amino-3-(N-phenyl)carbamoylisothiazole

: 119452-13-0
4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / CH₂Cl₂ / 1 h

2: 72 percent / ethanol / 1 h / Heating

3: 75 percent / KF-Al₂O₃ / acetonitrile / 2 h / Ambient temperature

With potassium fluoride on basic alumina; In ethanol; dichloromethane; acetonitrile;
DOI:10.1248/cpb.36.2902

Reference yield:

: 115106-42-8
4-(3',3'-dicyanoethenyl)amino-3-(N-phenyl)carbamoylisothiazole

: 119452-13-0
4,6-Dimethyl-7-phenyl-6,7-dihydro-4H-isothiazolo[4,3-e][1,4]diazepine-5,8-dione

Guidance literature:: Multi-step reaction with 4 steps

1: concentrated aq. HCl / ethanol

2: 85 percent / CH₂Cl₂ / 1 h

3: 72 percent / ethanol / 1 h / Heating

4: 75 percent / KF-Al₂O₃ / acetonitrile / 2 h / Ambient temperature

With hydrogenchloride; potassium fluoride on basic alumina; In ethanol; dichloromethane; acetonitrile;
DOI:10.1248/cpb.36.2902