ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate

Base Information

• Chemical Name: ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate
• CAS No.: 1012289-63-2
• Molecular Formula: C₁₅H₁₆N₂O₃S₂
• Molecular Weight: 336.436
• Mol file: 1012289-63-2.mol

Synonyms:ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate

Chemical Property of ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate

There total 2 articles about ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethyl 2-sulfanylacetate (623-51-8) + 2-chloro-N-(phenylthiazol-2-yl)acetamide (5039-16-7) → ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate (1012289-63-2)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Reflux;

DOI:10.1080/00397911.2011.591036

Reference yield:

2-Amino-4-phenylthiazole (2010-06-2) → ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate (1012289-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: potassium carbonate / acetone / 4 h / Reflux

With potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1080/00397911.2011.591036

Reference yield: 85.0%

ethyl 2-(2-oxo-2-(4-phenylthiazol-2-ylamino)ethylthio)acetate (1012289-63-2) → 4-(4-phenylthiazol-2-yl)thiomorpholine-3,5-dione (1400277-91-9)

Guidance literature:

With triethylamine; In ethanol; for 8h; Reflux;

DOI:10.1080/00397911.2011.591036

upstream raw materials:

ethyl 2-sulfanylacetate

2-chloro-N-(phenylthiazol-2-yl)acetamide

2-Amino-4-phenylthiazole

Downstream raw materials:

4-(4-phenylthiazol-2-yl)thiomorpholine-3,5-dione

2-amino-5-oxo-1-(4-phenylthiazol-2-yl)-4,5-dihydro-1H-pyrrole-3-carbonitrile