N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

Base Information

Chemical Name:N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide
CAS No.:1400707-15-4
Molecular Formula:C₂₃H₂₇N₅O₃
Molecular Weight:421.499
Hs Code.:

Synonyms:N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

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Chemical Property of N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

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Technology Process of N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

There total 5 articles about N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35613-84-4
isobutyramide oxime

: 1400706-58-2
N-(1-cyanopiperidin-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide

: 1400707-15-4
N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

Guidance literature:: isobutyramide oxime; N-(1-cyanopiperidin-4-yl)-N-cyclopropyl-4-oxazol-5-ylbenzamide; With zinc(II) chloride; In ethyl acetate; at 50 ℃; for 3h;

With acetic acid; In ethanol; at 100 ℃; for 2h;

Reference yield:

: 250161-45-6
4-(1,3-oxazol-5-yl)benzoic acid

: 1400707-15-4
N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 20 °C

4.1: zinc(II) chloride / ethyl acetate / 3 h / 50 °C

4.2: 2 h / 100 °C

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1400706-57-1
(N-cyclopropyl)-4-oxazol-5-yl-(N-piperidin-4-yl)benzamide

: 1400707-15-4
N-cyclopropyl-N-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-yl]-4-oxazol-5-ylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; tetrahydrofuran / 20 °C

2.1: zinc(II) chloride / ethyl acetate / 3 h / 50 °C

2.2: 2 h / 100 °C

With N-ethyl-N,N-diisopropylamine; zinc(II) chloride; In tetrahydrofuran; dichloromethane; ethyl acetate;