Technology Process of 2,4-dichlorophenyl 2-thiolanyl ketone
There total 3 articles about 2,4-dichlorophenyl 2-thiolanyl ketone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
at 50 - 55 ℃;
for 0.5h;
Yield given. Yields of byproduct given;
DOI:10.1248/cpb.38.1258
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 percent / Et3N / CH2Cl2 / 0.08 h / -15 °C
2: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / 50 - 55 °C
With
triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1248/cpb.38.1258
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) NaH / 1) DMF, 0 deg C, 15 min, 2) 0 deg C, 20 min
2: 71 percent / Et3N / CH2Cl2 / 0.08 h / -15 °C
3: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / 50 - 55 °C
With
sodium hydride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1248/cpb.38.1258
