Technology Process of 2-(2,4-Dichloro-phenyl)-6,7-dihydro-5H-[1,4]oxathiepine
There total 3 articles about 2-(2,4-Dichloro-phenyl)-6,7-dihydro-5H-[1,4]oxathiepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane;
at 50 - 55 ℃;
for 0.5h;
Yield given. Yields of byproduct given;
DOI:10.1248/cpb.38.1258
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 71 percent / Et3N / CH2Cl2 / 0.08 h / -15 °C
2: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / 50 - 55 °C
With
triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1248/cpb.38.1258
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) NaH / 1) DMF, 0 deg C, 15 min, 2) 0 deg C, 20 min
2: 71 percent / Et3N / CH2Cl2 / 0.08 h / -15 °C
3: lithium hexamethyldisilazide / tetrahydrofuran; hexane / 0.5 h / 50 - 55 °C
With
sodium hydride; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1248/cpb.38.1258
