[4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

Base Information

Chemical Name:[4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester
CAS No.:73736-62-6
Molecular Formula:C₃₁H₃₅FN₄O₃
Molecular Weight:530.642
Hs Code.:

Synonyms:[4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

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Chemical Property of [4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

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Technology Process of [4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

There total 9 articles about [4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.7%

: 73736-50-2
O-desmethyl astemizole

: 105-39-5
chloroacetic acid ethyl ester

: 73736-62-6
[4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetone;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 73736-62-6
[4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 46.7 percent / Na₂CO₃ / dimethylformamide / 20 h / 70 °C

4: 88.5 percent / H₂ / 10 percent Pd/C / methanol

5: 37.7 percent / K₂CO₃ / acetone

With hydrogen bromide; hydrogen; sodium carbonate; potassium carbonate; potassium iodide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 73736-62-6
[4-(2-{4-[1-(4-Fluoro-benzyl)-1H-benzoimidazol-2-ylamino]-piperidin-1-yl}-ethyl)-phenoxy]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 46.7 percent / Na₂CO₃ / dimethylformamide / 20 h / 70 °C

3: 88.5 percent / H₂ / 10 percent Pd/C / methanol

4: 37.7 percent / K₂CO₃ / acetone

With hydrogen bromide; hydrogen; sodium carbonate; potassium carbonate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00150a029