[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Base Information

Chemical Name:[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone
CAS No.:1421502-62-6
Molecular Formula:C₃₁H₃₁FN₈O₂
Molecular Weight:566.638
Hs Code.:

Synonyms:[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Suppliers and Price of [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Sigma-Aldrich
PF-06263276 ≥98% (HPLC)
25mg
$ 351.00

Sigma-Aldrich
PF-06263276 ≥98% (HPLC)
5mg
$ 87.10

ChemScene
PF-06263276 ≥99.0%
5mg
$ 450.00

ChemScene
PF-06263276 ≥99.0%
1mg
$ 195.00

Alichem
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1h-indazol-3-yl)-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone
1g
$ 1608.86

Alichem
(2-(6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1h-indazol-3-yl)-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl)(5-(piperidin-1-yl)pyrazin-2-yl)methanone
250mg
$ 631.25

Total 0 raw suppliers

Chemical Property of [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Chemical Property:

Boiling Point:921.1±65.0 °C(Predicted)
Density:1.394±0.06 g/cm3(Predicted)

Purity/Quality:: PF-06263276 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

There total 14 articles about [2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421502-64-8
{2-[6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1H-indazol-3-yl]-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl}-(5-piperidin-1-yl-pyrazin-2-yl)methanone sodium salt

: 1421502-62-6
[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Guidance literature:: With citric acid; In water; pH=4;

Reference yield:

: 1210707-88-2
5-(piperidin-1-yl)pyrazine-2-carboxylic acid

: 5-ethyl-2-fluoro-4-(3-(4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridin-2-yl)-1H-indazol-6-yl)phenol sulfate

: 1421502-62-6
[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Guidance literature:: 5-(piperidin-1-yl)pyrazine-2-carboxylic acid; With 1,1'-carbonyldiimidazole; In 1-methyl-pyrrolidin-2-one; for 2h; Inert atmosphere; Large scale;

5-ethyl-2-fluoro-4-(3-(4,5,6,7-tetrahydro-1H-imidazo-[4,5-c]pyridin-2-yl)-1H-indazol-6-yl)phenol sulfate; In 1-methyl-pyrrolidin-2-one; at 50 - 55 ℃; for 4h; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.9b00253

Reference yield:

: 34604-60-9
5-hydroxypyrazinoic acid

: 1421502-62-6
[2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-1 ,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl][5-(piperidin-1-yl)pyrazin-2-yl]methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / 0.5 h / -20 °C

1.2: 2 h / Reflux

2.1: trichlorophosphate / 1.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: water; sodium hydroxide / tetrahydrofuran / 4 h / 20 °C

4.2: pH 4 / Acidic conditions

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.33 h / 20 °C

5.2: 22.5 h / 20 °C

5.3: 18.5 h / 20 °C / pH 7

6.1: citric acid / water / pH 4

With thionyl chloride; water; N-ethyl-N,N-diisopropylamine; HATU; citric acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide;