34604-60-9

Usage

Uses

Used in Chemical Synthesis:
5-Hydroxypyrazine-2-carboxylic acid is used as a building block for [chemical synthesis] to facilitate the creation of new compounds and products. Its role as a building block is crucial due to its ability to be incorporated into various chemical structures, enhancing the development of new products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-Hydroxypyrazine-2-carboxylic acid is used as a key component for [the synthesis of new antituberculous agents]. As a metabolite of Pyrazinamide, it plays a significant role in the development of treatments against tuberculosis, a disease that requires continuous innovation in therapeutic approaches.
Used in Development of New Products:
5-Hydroxypyrazine-2-carboxylic acid is utilized as a vital element in the [attributes development] of new products, particularly in the chemical and pharmaceutical sectors. Its unique properties allow it to contribute to the enhancement of product attributes, making it an indispensable component in the development process.

InChI:InChI=1/C5H4N2O3/c8-4-2-6-3(1-7-4)5(9)10/h1-2H,(H,7,8)(H,9,10)

Upstream product

• 298-12-4 Glyoxilic acid 
• 18514-52-8 2,3-diaminomaleonitrile 
• 77168-76-4 3-carbamoyl-1,6-dihydro-6-oxo-2-pyrazinecarboxylic acid 
• 57005-60-4 1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile 
• 13924-96-4 4,5-dihydro-5-oxo-2-pyrazinecarboxamide 
• 82619-63-4 2-chloro-5-furan-2-yl-pyrazine 
• 82619-62-3 2-Hydroxy-5-(2'-furyl)pyrazine 
• 36070-80-1 5-chloropyrazinoic acid 

Downstream Products

• 88625-23-4 5-chloropyrazine-2-carbonyl chloride 
• 857355-32-9 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-pyrazinecarboxamide 
• 915948-98-0 azetidin-1-yl(5-chloropyrazin-2-yl)methanone 
• 36070-80-1 5-chloropyrazinoic acid 
• 1438853-99-6 5-chloro-N-(2-chlorophenyl)pyrazine-2-carboxamide 

Relevant academic research and scientific papers

Redesign of the Synthesis and Manufacture of an Azetidine-Bearing Pyrazine

Commercial route definition for a glucokinase activator called for a re-evaluation of the synthesis and processes used to access multikilogram quantities of a pyrazine building block. The processes developed allowed a literature route to sodium 6-oxo-1H-pyrazine-3-carboxylate to be leveraged. One of these processes consisted of a highly selective decarboxylation that allowed the target building block to be accessed with complete regioselectivity in standard batch processing equipment. The presence of an azetidine ring in the target required the mitigation of impurity liabilities arising from the use of the hydrochloride salt of azetidine as an input material.

AMIDE DERIVATIVES AND DRUGS

The present invention provides an amide derivative represented by the following formula [1]: wherein n represents 0 or 1; X represents CR4 or N; Y represents CR6 or N; Z represents CR7 or N; R1 and R2 may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R4, R5, R6 and R7 may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R3 represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. The compound of the present invention is useful as a TGF-β inhibitor.

Studies on Pyrazines. 7 (1). The Synthesis of 5-Chloropyrazinecarboxylic Acid

The titled carboxylic acid (1) was prepared by condensation of 2-furylglyoxal with aminoacetamide followed by chlorination of the resulting 2-hydroxy-5-(2'-furyl)pyrazine (2) and permanganate oxidation.The acid was further converted into methyl ester and 5-hydroxypyrazinecarboxylic acid.