(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

Base Information

Chemical Name:(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one
CAS No.:1381848-83-4
Molecular Formula:C₄₆H₇₆O₈Si₂
Molecular Weight:813.276
Hs Code.:

(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

Synonyms:(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

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Chemical Property of (2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

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Technology Process of (2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

There total 35 articles about (2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1381848-84-5
C₅₄H₈₄O₉Si₂

: 1381848-83-4
(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃; for 1.5h;
DOI:10.1021/ol301278e

Reference yield:

: 1381848-71-0
(4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyltetrahydro-2H-pyran-2-one

: 1381848-83-4
(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.42 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C

2.2: 0.67 h

2.3: 14 h / 20 °C

3.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / methanol; dichloromethane / 1.5 h / 0 °C

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 27 h / 0 - 20 °C / Molecular sieve

5.1: camphor-10-sulfonic acid / methanol; dichloromethane / 2.5 h / 0 °C

6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1.5 h / 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrapropylammonium perruthennate; camphor-10-sulfonic acid; potassium hexamethylsilazane; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; 9-bora-bicyclo[3.3.1]nonane; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/ol301278e

Reference yield:

: 1381848-73-2
(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

: 1381848-83-4
(2R,4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-3-hydroxy-2-methylbutan-2-yl)-2-(((2S,4S,5S,6S)-6-(2-hydroxyethyl)-5-methyl-4-((triisopropylsilyl)oxy)tetrahydro-2H-pyran-2-yl)methyl)-2-methoxy-4-methyldihydro-2H-pyran-3(4H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 0.67 h

1.3: 14 h / 20 °C

2.1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / methanol; dichloromethane / 1.5 h / 0 °C

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 27 h / 0 - 20 °C / Molecular sieve

4.1: camphor-10-sulfonic acid / methanol; dichloromethane / 2.5 h / 0 °C

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1.5 h / 20 °C

With tetrapropylammonium perruthennate; camphor-10-sulfonic acid; sodium hydrogencarbonate; 4-methylmorpholine N-oxide; 9-bora-bicyclo[3.3.1]nonane; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/ol301278e