(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

Base Information

Chemical Name:(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate
CAS No.:1381848-73-2
Molecular Formula:C₃₄H₅₁F₃O₆SSi₂
Molecular Weight:701.008
Hs Code.:

(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

Synonyms:(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

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Chemical Property of (2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

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Technology Process of (2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

There total 20 articles about (2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1381848-71-0
(4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyltetrahydro-2H-pyran-2-one

: 1381848-73-2
(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

Guidance literature:: (4R,6R)-6-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyltetrahydro-2H-pyran-2-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.416667h;

N,N-phenylbistrifluoromethane-sulfonimide; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;
DOI:10.1021/ol301278e

Reference yield:

: 1381848-66-3
C₁₇H₃₈O₄Si

: 1381848-73-2
(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: camphor-10-sulfonic acid / methanol / 0.67 h / 0 °C

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 7.5 h / 20 °C

3.2: 2.5 h

4.1: 1H-imidazole / dichloromethane / 3.5 h / 20 °C

5.1: N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.42 h / -78 °C

5.2: 0.5 h / -78 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid; potassium hexamethylsilazane; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ol301278e

Reference yield:

: 1381848-64-1
C₁₁H₂₂O₂

: 1381848-73-2
(2R,4R)-2-((S)-4-((tert-butyldiphenylsilyl)oxy)-2-methyl-3-((triethylsilyl)oxy)butan-2-yl)-4-methyl-3,4-dihydro-2H-pyran-6-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / tetrahydrofuran / 1.5 h / 20 °C

2.1: osmium(VIII) oxide; potassium hexacyanoferrate(III); (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); potassium carbonate / water / 15 h / 0 °C

3.1: 1H-imidazole / tetrahydrofuran / 4 h / 0 - 20 °C

4.1: camphor-10-sulfonic acid / methanol / 0.67 h / 0 °C

5.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 7.5 h / 20 °C

5.2: 2.5 h

6.1: 1H-imidazole / dichloromethane / 3.5 h / 20 °C

7.1: N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.42 h / -78 °C

7.2: 0.5 h / -78 °C

With 1H-imidazole; N,N,N,N,N,N-hexamethylphosphoric triamide; osmium(VIII) oxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; (8a,9R,8′′′a,9′′′R)-9,9′-[(2,5-diphenylpyrimidine-4,6-diyl)bis(oxy)]bis(6′-methoxy-10,11-dihydrocinchonan); [bis(acetoxy)iodo]benzene; potassium hexacyanoferrate(III); camphor-10-sulfonic acid; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; water; toluene;
DOI:10.1021/ol301278e