2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione

Base Information

• Chemical Name: 2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione
• CAS No.: 354145-87-2
• Molecular Formula: C₅₇H₄₃Br₄NO₈
• Molecular Weight: 1189.59
• Mol file: 354145-87-2.mol

Synonyms:2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione

Chemical Property of 2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione

There total 1 articles about 2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

potassium phtalimide (1074-82-4) + C49H39Br5O6 (134868-86-3) → 2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione (354145-87-2)

Guidance literature:

With potassium carbonate; In acetonitrile; for 3h; Heating;

DOI:10.1021/ja010257c

Reference yield: 96.0%

2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione (354145-87-2) → 3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzylamine (354145-88-3)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; ethanol; for 2h; Heating;

DOI:10.1021/ja010257c

Reference yield:

2-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-isoindole-1,3-dione (354145-87-2) → N-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-4-diphenylphosphanyl-benzamide (352212-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂NNH₂*H₂O / ethanol; tetrahydrofuran / 2 h / Heating

2: 79 percent / 1-hydroxybenzotiazole hydrate; 1,3-dicyclohexylcarbodiimide / CHCl₃ / 3 h / 20 °C

With benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1021/ja010257c

upstream raw materials:

potassium phtalimide

C₄₉H₃₉Br₅O₆

Downstream raw materials:

3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzylamine

N-{3,5-bis-[3,5-bis-(4-bromo-benzyloxy)-benzyloxy]-benzyl}-4-diphenylphosphanyl-benzamide