Technology Process of methyl 3-(N-ethoxycarbonylacetylamino)-5-phenylpentanoate
There total 5 articles about methyl 3-(N-ethoxycarbonylacetylamino)-5-phenylpentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine; dicyclohexyl-carbodiimide;
In
dichloromethane;
for 21.5h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83.5 percent / pyridine / 7 h / 100 °C
2: 88 percent / hydroxylamine hydrochloride, anhydrous sodium acetate / ethanol / 1.) reflux, 90 min, 2.) room temperature, 3 h
3: 89 percent / H2 / 5percent palladium on carbon / acetic acid
4: 92 percent / SOCl2 / 5 h / Ambient temperature
5: 76 percent / Et3N, N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 21.5 h / Ambient temperature
With
thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
pyridine; ethanol; dichloromethane; acetic acid;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / hydroxylamine hydrochloride, anhydrous sodium acetate / ethanol / 1.) reflux, 90 min, 2.) room temperature, 3 h
2: 89 percent / H2 / 5percent palladium on carbon / acetic acid
3: 92 percent / SOCl2 / 5 h / Ambient temperature
4: 76 percent / Et3N, N,N'-dicyclohexylcarbodiimide / CH2Cl2 / 21.5 h / Ambient temperature
With
thionyl chloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
ethanol; dichloromethane; acetic acid;
