(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide
CAS No.:459143-33-0
Molecular Formula:C₁₉H₂₉NO₂
Molecular Weight:303.445
Hs Code.:

Synonyms:(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

Suppliers and Price of (1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

There total 1 articles about (1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110-96-3
diisobutylamine

: 63106-93-4,96847-52-8,96847-75-5,96847-53-9
(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 459143-33-0
(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

Guidance literature:: With aluminium trichloride; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0968-0896(02)00030-5

Reference yield: 77.0%

: 459143-33-0
(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

: 459143-40-9
(1S,2R)-1-phenyl-2-formyl-N,N-di-isobutylcyclopropanecarboxamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃;
DOI:10.1016/S0968-0896(02)00030-5

Reference yield:

: 459143-33-0
(1S,2R)-1-phenyl-2-(hydroxymethyl)-N,N-di-isobutylcyclopropanecarboxamide

: (1S,2R)-1-phenyl-2-[(S)-1-aminopropyl]-N,N-di-isobutylcyclopropanecarboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: 77 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

2.1: 82 percent / tetrahydrofuran; diethyl ether / 3 h / -15 °C

3.1: PPh₃CBr₄ / hexamethylphosphoric acid triamide / 0.5 h / 0 °C

3.2: 68 percent / NaN₃ / hexamethylphosphoric acid triamide / 6 h / 20 °C

4.1: 87 percent / H₂ / 10 percent Pd/C / methanol / 18 h / 20 °C / atmospheric pressure

With oxalyl dichloride; carbon tetrabromide; hydrogen; dimethyl sulfoxide; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; dichloromethane; 1.1: Swern oxidation / 2.1: Grignard reaction;
DOI:10.1016/S0968-0896(02)00030-5