N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine

Base Information

• Chemical Name: N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine
• CAS No.: 452303-41-2
• Molecular Formula: C₃₂H₄₁N₃O₈
• Molecular Weight: 595.693

Synonyms:N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine

Chemical Property of N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine

Chemical Property:

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Technology Process of N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine

There total 3 articles about N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N6-[(benzyloxy)carbonyl]-L-lysine (1155-64-2,57705-97-2,67178-46-5,25931-47-9) + glutaric acid 5-N-benzoyloxy-N-cyclohexyl monoamide → N2-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N6-benzyloxycarbonyl-L-lysine (452303-41-2)

Guidance literature:

glutaric acid 5-N-benzoyloxy-N-cyclohexyl monoamide; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.75h;

N₆-[(benzyloxy)carbonyl]-L-lysine; With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 2h;

DOI:10.1016/S0968-0896(02)00044-5

Reference yield:

glutaric anhydride, (108-55-4) → N2-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N6-benzyloxycarbonyl-L-lysine (452303-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃Nz

2.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

2.2: 70 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1016/S0968-0896(02)00044-5

Reference yield:

N-cyclohexyl-O-benzoylhydroxylamine (1485-75-2) → N2-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N6-benzyloxycarbonyl-L-lysine (452303-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃Nz

2.1: i-BuOCOCl; N-methylmorpholine / tetrahydrofuran / 0.75 h / -10 °C

2.2: 70 percent / Et₃N / tetrahydrofuran / 2 h / -10 - 20 °C

With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran;

DOI:10.1016/S0968-0896(02)00044-5

upstream raw materials:

N₆-[(benzyloxy)carbonyl]-L-lysine

glutaric anhydride,

N-cyclohexyl-O-benzoylhydroxylamine

Downstream raw materials:

N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-lysine

N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-L-lysine

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