1485-75-2

Upstream product

• 29456-22-2 cyclohexanone oxime benzoyl ester 
• 108-91-8 cyclohexylamine 
• 94-36-0 dibenzoyl peroxide 
• 100-64-1 cyclohexanone-oxime 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1485-64-9 N-Cyclohexyl-N-benzoyloxy-N'-phenyl-harnstoff 
• 5459-93-8 N-ethyl-cyclohexanamine 
• 1759-68-8 N-benzoylcyclohexylamine 
• 64934-62-9 N-benzoyloxy-N-cyclohexylbenzamide 
• 452303-38-7 L-glutamic acid 5-(N-benzyloxy-N-cyclohexyl)amide 
• 452303-49-0 N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-L-lysine 
• 452303-41-2 N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-benzyloxycarbonyl-L-lysine 
• 439152-26-8 N-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-glutamic acid 5-(N-benzyloxy-N-cyclohexyl)amide 
• 439152-29-1 N²-[4-(N-benzyloxy-N-cyclohexylcarbamoyl)-n-butanoyl]-N⁶-[N^2',N^6'-bis(2,3-diacetoxybenzoyl)-L-lysyl]-L-lysine 
• 1660-83-9 1-cyclohexyl-1-hydroxy-3-phenyl-urea 
• 1500-28-3 2-cyclohexyl-4-phenyl-[1,2,4]oxadiazolidine-3,5-dione 
• 108-94-1 cyclohexanone 
• 1510821-74-5 2-(2-(cyclohexylamino)phenyl)-5-methyl-1H-pyrazol-3(2H)-one 
• 1510821-80-3 2-(2-(cyclohexylamino)-5-(trifluoromethyl)phenyl)-5-methyl-1H-pyrazol-3(2H)-one 

Relevant academic research and scientific papers

Direct N-O bond formation via oxidation of amines with benzoyl peroxide

Herein, we report a general and efficient method for direct N-O bond formation without undesirable C-N bond (amide) formation starting from commercially available amines and benzoyl peroxide. The oxidation of 1,2-diamines to furnish bis-(benzoyloxy)-1,2-diamines is reported for the first time. We found that a significant amount of water (BPO?:?water = 3?:?1) in combination with Cs2CO3 is necessary to achieve high selectivity and yield. The reaction conditions are applicable to a wide range of 1,2-diamine and 1,2-disubstituted-1,2-diamine substrates. Additionally this method is highly applicable to primary and secondary amines. Further, the present method can access chiral bis-hydroxamic acids and bis-hydroxyl amines in just two steps from 1,2-diamines. The reaction conditions are simple, mild and inert atmosphere free. The synthetic potential of this methodology is further demonstrated in the short synthesis of a chiral BHA ligand.

Rhodium(III)-catalyzed C–H amination of 2-arylquinazolin-4(3H)-one with N-alkyl-O-benzoyl-hydroxylamines

N-benzoate alkylamines were used as the aminating agents, a efficient Rh-catalyzed ortho C–H amination of 2-arylquinazolin-4(3H)-one has been reported. The reactions exhibit high efficient and good functional group tolerance. Exclusive 2,6-bis-aminated pr

Amide groups switch selectivity: C-H trifluoromethylation of α,β-unsaturated amides and subsequent asymmetric transformation

The first direct C-H β-trifluoromethylation of unsubstituted or α-alkyl-substituted α,β-unsaturated carbonyl compounds under metal-free conditions was realized with excellent regio- and stereoselectivity as well as a very broad substrate scope. Both olefi

Synthesis of secondary amines via N-(benzoyloxy)amines and organoboranes

A variety of primary amines (R-NH2) were converted to their corresponding N-(benzoyloxy)amines (i.e., R-NHOCOPh) under biphasic conditions in excellent yields (63-90%). The intermediate N- (benzoyloxy)amines were converted to their N-ethylamine derivatives upon reaction with triethylborane in THF in good yield (54-89%). These experiments demonstrated the similar chemistry of N-chloro- and N-(benzoyloxy)amines with organoboranes.

REDUCTION OF O-ACYL OXIMES

NaCNBH3/AcOH and Et3SiH/CF3CO2H were found to be excellent reducing reagents for oxime benzoates without cleaving the N-O bond.