3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester

Base Information

• Chemical Name: 3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester
• CAS No.: 873297-69-9
• Molecular Formula: C₃₂H₅₄O₄Si₂
• Molecular Weight: 558.949
• Mol file: 873297-69-9.mol

Synonyms:3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester

Chemical Property of 3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester

There total 1 articles about 3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

(3R,4S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-methylene-2-oxo-3-(3-trimethylsilanyl-but-3-enyl)-octanoic acid methyl ester (873297-62-2) + Methyltriphenylphosphonium bromide (1779-49-3) → 3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester (873297-69-9)

Guidance literature:

Methyltriphenylphosphonium bromide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 1h;

(3R,4S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-methylene-2-oxo-3-(3-trimethylsilanyl-but-3-enyl)-octanoic acid methyl ester; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ol052462t

Reference yield: 77.0%

3-[2-(3-benzyloxy-propyl)-1-(tert-butyl-dimethyl-silanyloxymethyl)-allyl]-2-methylene-6-trimethylsilanyl-hept-6-enoic acid methyl ester (873297-69-9) → (4R,5S)-5-(4-Benzyloxy-1-methylene-butyl)-3-methylene-4-(3-trimethylsilanyl-but-3-enyl)-tetrahydro-pyran-2-one

Guidance literature:

With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/ol052462t

upstream raw materials:

(3R,4S)-8-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxymethyl)-5-methylene-2-oxo-3-(3-trimethylsilanyl-but-3-enyl)-octanoic acid methyl ester

Methyltriphenylphosphonium bromide