Sodium pyridine-2-sulfinate

Base Information

• Chemical Name: Sodium pyridine-2-sulfinate
• CAS No.: 24367-66-6
• Molecular Formula: C₅H₄NO₂S*Na
• Molecular Weight: 165.148
• Mol file: 24367-66-6.mol

Synonyms:2-pyridinesulfinic acid sodium salt

Chemical Property of Sodium pyridine-2-sulfinate

Chemical Property:

• Melting Point: 292°C
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water

Purity/Quality:

98%,99%, ^*data from raw suppliers

Sodium Pyridine-2-sulfinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: This 2-pyridylsulfinate enables Suzuki-Miyaura cross coupling with aryl halides to access diverse pyridine derivatives as reported by the laboratory of Michael Willis.. No longer impeded by unstable 2-pyridyl boronates, the sulfinate alternatives provide Pd-catalyzed coupling routes to therapeutically valuable pyridine rings.

Technology Process of Sodium pyridine-2-sulfinate

There total 1 articles about Sodium pyridine-2-sulfinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(Pyridine-2-sulfonyl)-benzothiazole (95091-07-9) → 1,3-Benzothiazole (95-16-9) + 2-pyridinesulfinic acid sodium salt (24367-66-6)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.5h; Ambient temperature;

DOI:10.1246/cl.1984.2125

Reference yield: 95.0%

2-pyridinesulfinic acid sodium salt (24367-66-6) + 1-Bromo-4-fluorobenzene (460-00-4) → 4-fluorophenylpyridine (58861-53-3)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 150 ℃; for 16h; Reagent/catalyst; Catalytic behavior; Kinetics; Inert atmosphere; Sealed tube; Microwave irradiation;

DOI:10.1021/jacs.9b13260

Reference yield: 90.0%

1-Bromonaphthalene (90-11-9) + 2-pyridinesulfinic acid sodium salt (24367-66-6) → 2-naphthylpyridine (76759-26-7)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In 1,4-dioxane; at 150 ℃;

DOI:10.1039/c7sc00675f

upstream raw materials:

2-(Pyridine-2-sulfonyl)-benzothiazole

Downstream raw materials:

2-<(phenylmethyl)sulfonyl>pyridine

3-(pyridine-2-sulfonyl)thiophene-2-carbaldehyde

pyridine-2-sulfonyl chloride

4-methyl-3-(pyridine-2-sulfonyl)thiophene-2-carbaldehyde

Refernces