Technology Process of (3S,4R)-4-amino-1-N-Boc-3-dimethoxytrityloxypyrrolidine
There total 6 articles about (3S,4R)-4-amino-1-N-Boc-3-dimethoxytrityloxypyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; hydrogen;
In
ethanol;
for 6h;
under 517.162 Torr;
DOI:10.1016/j.tet.2009.08.019
- Guidance literature:
-
Multi-step reaction with 5 steps
1: dmap; triethylamine / methanol / 18 h / 20 °C
2: pyridine / 4 h / 20 °C
3: dmap / dichloromethane / 1 h / 0 - 20 °C
4: sodium azide / dimethyl sulfoxide / 18 h / 100 °C
5: triphenylphosphine / tetrahydrofuran / 18 h / 20 °C
With
pyridine; dmap; sodium azide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dmap / dichloromethane / 1 h / 0 - 20 °C
2: sodium azide / dimethyl sulfoxide / 18 h / 100 °C
3: triphenylphosphine / tetrahydrofuran / 18 h / 20 °C
With
dmap; sodium azide; triphenylphosphine;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
