926913-07-7

Upstream product

• 762-75-4 tert-butyl formate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 150986-62-2 S,S-3,4-dihydroxypyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1374429-77-2 (3R,4S)-tert-butyl 3-azido-4-(bis(4-methoxyphenyl)(phenyl)methoxy)pyrrolidine-1-carboxylate 
• 1412256-91-7 (3R,4S)-tert-butyl 3-(benzyloxycarbonylamino)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)pyrrolidine-1-carboxylate 
• 1193318-61-4 (3S,4R)-4-amino-1-N-Boc-3-dimethoxytrityloxypyrrolidine 
• 926913-24-8 (3S,4R)-4-(adenin-9-yl)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)pyrrolidine 
• 926913-27-1 (3S,4S)-4-(adenin-9-yl)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)pyrrolidine 
• 926913-22-6 (3S,4R)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)-4-(thymin-1-yl)-pyrrolidine 
• 926913-26-0 (3S,4S)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)-4-(thymin-1-yl)-pyrrolidine 
• 926913-20-4 (3R,4S)-1-N-tert-butyloxycarbonyl-4-(4,4'-dimethoxytrityloxy)-3-mesyloxy-pyrrolidine 
• 926913-17-9 (3S,4R)-1-N-tert-butyloxycarbonyl-3-(4,4'-dimethoxytrityloxy)-4-hydroxypyrrolidine 
• 926913-11-3 (3S,4S)-1-N-tert-butyloxycarbonyl-4-(4,4'-dimethoxytrityloxy)-3-mesyloxy-pyrrolidine 

Relevant academic research and scientific papers

TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS

Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

Synthesis of diastereomeric 3-hydroxy-4-pyrrolidinyl derivatives of nucleobases

The work deals with the synthesis of hydroxypyrrolidine analogs of nucleosides. Starting from the optically pure l- or d-tartaric acid, we improved the synthesis of enantiomeric trans-3,4-dihydroxypyrrolidines and elaborated a procedure for the synthesis of all possible diastereoisomers of 3-hydroxy-4-pyrrolidinyl derivatives of both purine and pyrimidine nucleobases. The prepared compounds were tested for cytostatic and antiviral properties but no significant activity was found.