N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine

Base Information

Chemical Name:N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine
CAS No.:1010423-89-8
Molecular Formula:C₁₆H₁₈F₃NO₂
Molecular Weight:313.32
Hs Code.:

Synonyms:N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine

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Chemical Property of N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine

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Technology Process of N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine

There total 1 articles about N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1514-82-5
2-bromo-3,3,3-trifluoropropene

: 131319-74-9
(R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine

: 1010423-89-8
N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine

Guidance literature:: 2-bromo-3,3,3-trifluoropropene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

(R)-2,3-di-O-isoproylideneglyceraldehyde N-benzylimine; In tetrahydrofuran; for 1.5h; Further stages.;
DOI:10.1016/j.jfluchem.2007.02.010

Reference yield:

: 1010423-89-8
N-benzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-4,4,4-trifluorobut-2-yn-1-amine

: 122565-28-0,23809-57-6
(S)-2-amino-5,5,5-trifluoropentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / H₂ / palladium on charcoal / ethyl acetate / 8 h / 20 °C / 760.05 Torr

2: 82 percent / p-toluenesulfonic acid monohydrate / methanol

3: 82 percent / NaIO₄; RuCl₃ / CCl₄; acetonitrile; H₂O / 6 h / 20 °C

4: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 20 °C

With ruthenium trichloride; sodium periodate; hydrogen; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1016/j.jfluchem.2007.02.010