(R)-Boc-5-oxopyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: (R)-Boc-5-oxopyrrolidine-2-carboxylic acid
• CAS No.: 160347-90-0
• Molecular Formula: C₁₀H₁₅NO₅
• Molecular Weight: 229.233
• Hs Code.: 2933790090
• European Community (EC) Number: 625-119-0
• DSSTox Substance ID: DTXSID70595352
• Wikidata: Q72450598
• Mol file: 160347-90-0.mol

Synonyms:160347-90-0;BOC-D-PYR-OH;(R)-Boc-5-oxopyrrolidine-2-carboxylic acid;(R)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic acid;(2R)-1-[(tert-butoxy)carbonyl]-5-oxopyrrolidine-2-carboxylic acid;N-Boc-5-oxo-D-proline;boc-d-pyroglutamic acid;(2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]-5-oxopyrrolidine-2-carboxylic acid;MFCD08458561;SCHEMBL4174747;DTXSID70595352;MJLQPFJGZTYCMH-ZCFIWIBFSA-N;(R)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylicacid;AMY34367;AKOS015892816;1-(tert-Butoxycarbonyl)-5-oxo-D-proline;AS-47588;CS-0053506;F14483;(2R)-1-Boc-5-oxopyrrolidine-2-carboxylic acid;EN300-6474687;A850849;(R)-(+)-1-Boc-5-oxopyrrolidine-2-carboxylic acid;(R)-Boc-5-oxopyrrolidine-2-carboxylic acid, 97%;J-009710;(R)-5-oxo-1,2-Pyrrolidinedicarboxylic acid tert-butyl ester;(2R)-1-(TERT-BUTOXYCARBONYL)-5-OXOPYRROLIDINE-2-CARBOXYLIC ACID

Chemical Property of (R)-Boc-5-oxopyrrolidine-2-carboxylic acid

Chemical Property:

• Melting Point: 111-116℃
• Boiling Point: 425.8±38.0 °C(Predicted)
• PKA: 3.04±0.20(Predicted)
• PSA: 83.91000
• Density: 1.304
• LogP: 0.93500
• Storage Temp.: Store at RT
• Sensitive.: Moisture Sensitive
• Water Solubility.: Slightly soluble in water.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 229.09502258
• Heavy Atom Count: 16
• Complexity: 331

Purity/Quality:

98% ^*data from raw suppliers

(R)-Boc-5-oxopyrrolidine-2-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N1C(CCC1=O)C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)N1[C@H](CCC1=O)C(=O)O
• Uses: Used as pharmaceutical intermediates and anesthetic agent.

Technology Process of (R)-Boc-5-oxopyrrolidine-2-carboxylic acid

There total 10 articles about (R)-Boc-5-oxopyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate (113400-36-5,400626-71-3) → L-N-t-butoxycarbonylpyroglutamic acid (53100-44-0,160347-90-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 120h; Ambient temperature;

DOI:10.1039/p19960000507

Reference yield: 83.0%

4-nitrobenzyl L-1-tert-butoxycarbonylpyroglutamate (108963-97-9) → L-N-t-butoxycarbonylpyroglutamic acid (53100-44-0,160347-90-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h; Ambient temperature;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → L-N-t-butoxycarbonylpyroglutamic acid (53100-44-0,160347-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.0 g / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 384 h / 20 °C

2: 93 percent / H₂ / Pd-C / methanol / 6 h

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2007.03.005

upstream raw materials:

L-glutamic acid

2-hydroxymethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

4-nitrobenzyl L-1-tert-butoxycarbonylpyroglutamate

benzyl (2S)-N-tert-butoxycarbonyl-5-oxoprolinate

Downstream raw materials:

2-hydroxymethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester

pyroGlu-Leu

L-pyroglutamyl-valine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 160347-90-0 BOC-D-PYR-OH

Send

Send

Metric Ton KG G Pound L ML

Send

Send