N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Base Information

Chemical Name:N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine
CAS No.:1204331-40-7
Molecular Formula:C₂₇H₂₅F₃N₄O₅
Molecular Weight:542.515
Hs Code.:

Synonyms:N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

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Chemical Property of N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

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Technology Process of N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

There total 14 articles about N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.7%

: N''-benzyloxycarbonylguanidine

: 1204331-39-4
4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoic acid

: 1204331-40-7
N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Guidance literature:: 4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoic acid; With 2-chloro-1-methyl-pyridinium iodide; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1.5h;

N''-benzyloxycarbonylguanidine; With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1204331-40-7
N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -75 °C

1.2: -75 - 0 °C

1.3: 0.17 h / Cooling

2.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 4 h / 140 °C / Sealed tube

4.1: water; potassium carbonate / methanol / 2 h / 60 °C

4.2: pH ~ 4

5.1: hydrogen / palladium 10% on activated carbon / methanol / 3102.97 Torr

6.1: hydrogenchloride / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

8.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

9.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

9.2: 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hexamethyldisilazane; (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water; 3.1: Suzuki Coupling;

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1204331-40-7
N-{4-[1-(furan-2-carbonyl)-piperidin-4-yl]-3-trifluoromethyl-benzoyl}-N'-(carbobenzyloxy)-guanidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium acetate / (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C

3.1: water; sodium hydroxide / ethanol / 2 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / methanol / 3102.97 Torr

5.1: hydrogenchloride / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 20 °C

7.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

8.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

8.2: 20 °C

With hydrogenchloride; lithium hydroxide monohydrate; 2-chloro-1-methyl-pyridinium iodide; water; hydrogen; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (diphenylphosphin)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; N,N-dimethyl-formamide; 2.1: Suzuki Coupling;