Methyl (R)-1-Trityl-2-aziridinecarboxylate

Base Information

• Chemical Name: Methyl (R)-1-Trityl-2-aziridinecarboxylate
• CAS No.: 160233-42-1
• Molecular Formula: C23H21 N O2
• Molecular Weight: 343.425
• Hs Code.: 2933990090
• European Community (EC) Number: 852-131-5
• DSSTox Substance ID: DTXSID10448595
• Mol file: 160233-42-1.mol

Synonyms:160233-42-1;Methyl (R)-1-Trityl-2-aziridinecarboxylate;(R)-Methyl 1-tritylaziridine-2-carboxylate;methyl (2R)-1-(triphenylmethyl)aziridine-2-carboxylate;(R)-1-Trityl-aziridine-2-carboxylic acid methyl ester;methyl (2R)-1-tritylaziridine-2-carboxylate;2-Aziridinecarboxylic acid, 1-(triphenylmethyl)-, methyl ester, (2R)-;MFCD09878842;METHYL(R)-1-TRITYL-2-AZIRIDINECARBOXYLATE;SCHEMBL2298094;DTXSID10448595;AMY21544;AKOS022172748;AS-38097;CS-0049299;EN300-6763837

Chemical Property of Methyl (R)-1-Trityl-2-aziridinecarboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.623
• Boiling Point: 430.3°Cat760mmHg
• PKA: 2.57±0.40(Predicted)
• Flash Point: 133.3°C
• PSA: 29.31000
• Density: 1.195g/cm³
• LogP: 3.77360
• Storage Temp.: 2-8°C
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 343.157228913
• Heavy Atom Count: 26
• Complexity: 427

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl(2R)-1-(triphenylmethyl)aziridine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)C1CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4
• Isomeric SMILES: COC(=O)[C@H]1CN1C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of Methyl (R)-1-Trityl-2-aziridinecarboxylate

There total 8 articles about Methyl (R)-1-Trityl-2-aziridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2R)-3-hydroxy-2-(tritylamino)propanoic acid methyl ester (116457-91-1) → (2R)-1-tritylaziridine-2-carboxylic acid methyl ester (160233-42-1)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 24h;

Reference yield: 80.0%

O-mesyl-N-trityl-D-serine methyl ester (116457-92-2) → (2R)-1-tritylaziridine-2-carboxylic acid methyl ester (160233-42-1)

Guidance literature:

With triethylamine; In 1,2-dimethoxyethane; Reflux;

Reference yield:

C24H25NO5S → (2R)-1-tritylaziridine-2-carboxylic acid methyl ester (160233-42-1)

Guidance literature:

In tetrahydrofuran; for 48h; Reflux;

DOI:10.1016/j.tet.2014.06.011

upstream raw materials:

(2R)-3-hydroxy-2-(tritylamino)propanoic acid methyl ester

O-mesyl-N-trityl-D-serine methyl ester

triethylamine

trityl chloride

Downstream raw materials:

methyl (2R)-N-(4-methylphenyl)sulfonylaziridine-2-carboxylate

methyl (R)-N-(p-nitrobenzenesulfonyl)aziridine-2-carboxylate

O₁-benzyl-O₂-methyl-(2R)-aziridine-1,2-dicarboxylate

(-)-(R)-N₁-(triphenylmethyl)aziridine-2-carboxamide

Refernces

• 1、 -. "Aryl substituted aminotetrahydropyran compound and use thereof". Paragraph 0368; 0372; 0373. . Retrieved 2019/07/04.
• 2、 -. "LZC696 intermediate and synthetic method therefor". . . Retrieved 2016/10/09.