trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

Base Information

Chemical Name:trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate
CAS No.:97974-83-9
Molecular Formula:C₃₆H₄₃I₂NO₅
Molecular Weight:823.55
Hs Code.:

Synonyms:trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

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Chemical Property of trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

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Technology Process of trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

There total 12 articles about trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 108-24-7
acetic anhydride

: 97974-82-8
trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethanol

: 97974-83-9
trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

Guidance literature:: With dmap; triethylamine;
DOI:10.1021/jo00219a061

Reference yield:

: 2314-37-6
3-iodo-4-methoxybenzaldehyde

: 97974-83-9
trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) dimethoxyethane, RT, 1 h, 2.) dimethoxyethane, RT, 6 h

2: 71 percent / lithium triethylborohydride / tetrahydrofuran; CH₂Cl₂ / 0.5 h

3: 92 percent / p-toluenesulfono hydrazide, aq. sodium acetate / 1,2-dimethoxy-ethane / Heating

4: 85 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 72 h / Ambient temperature

With dmap; sodium acetate; sodium hydride; lithium triethylborohydride; triethylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo00230a003

Reference yield:

: 97974-78-2
(4α,6α,8α,9aα)-(+/-)--3-(dimethylphosphinyl)-2-propanone

: 97974-83-9
trans-<4α(S*),6α,8α,9aα>-(+/-)-octahydro-6-(3-iodo-4-methoxyphenyl)-α-<2-(3-iodo-4-methoxyphenyl)ethyl>-8-(phenylmethoxy)-2H-quinolizine-4-ethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) dimethoxyethane, RT, 1 h, 2.) dimethoxyethane, RT, 6 h

2: 71 percent / lithium triethylborohydride / tetrahydrofuran; CH₂Cl₂ / 0.5 h

3: 92 percent / p-toluenesulfono hydrazide, aq. sodium acetate / 1,2-dimethoxy-ethane / Heating

4: 85 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / 72 h / Ambient temperature

With dmap; sodium acetate; sodium hydride; lithium triethylborohydride; triethylamine; toluene-4-sulfonic acid hydrazide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jo00230a003