methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

Base Information

Chemical Name:methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate
CAS No.:128659-76-7
Molecular Formula:C₂₄H₂₉N₃O₅
Molecular Weight:439.511
Hs Code.:

methyl 4-<N-(1-oxopropyl)-N-phenylamino>-1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

Synonyms:methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

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Chemical Property of methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

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Technology Process of methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

There total 1 articles about methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 5339-26-4
(4-nitrophenyl)ethyl bromide

: 72996-78-2
methyl 4-[N-(1-oxopropyl)-N-phenylamino]-4-piperidinecarboxylate

: 128659-76-7
methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

Guidance literature:: With triethylamine; In acetonitrile; at 70 ℃; for 24h;
DOI:10.1021/jm00171a020

Reference yield:

: 128659-76-7
methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

: 128659-77-8
methyl 4--1-<2-(4-aminophenyl)ethyl>-4-piperidinecarboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 3h; under 3040 Torr; Yield given;
DOI:10.1021/jm00171a020

Reference yield:

: 128659-76-7
methyl 4--1-<2-(4-nitrophenyl)ethyl>-4-piperidinecarboxylate

: azidocarfentanil

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 3 h / 3040 Torr

2: 1.) sodium nitrite, TFA, concd. HCl, 2.) NaN₃, Na₂CO₃ / 1.) H₂O, -20 deg C, 30 min, 2.) RT, 30 min, pH 7.5

With hydrogenchloride; sodium azide; hydrogen; sodium carbonate; trifluoroacetic acid; sodium nitrite; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00171a020