(R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Base Information

Chemical Name:(R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide
CAS No.:1043450-51-6
Molecular Formula:C₂₁H₂₅F₂NO₄
Molecular Weight:393.431
Hs Code.:

Synonyms:(R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

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Chemical Property of (R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Chemical Property:

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Technology Process of (R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

There total 9 articles about (R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1043450-50-5
(S)-3-((R)-6-(4-fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)hexanoyl)-4-isopropyloxazolidin-2-one

: 1043450-51-6
(R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Guidance literature:: With hydroxylamine; potassium cyanide; In tetrahydrofuran; methanol; water; at 20 ℃; for 72h;

Reference yield:

: 1043450-40-3
2-(4-fluoro-3-methylphenoxy)acetyl chloride

: 1043450-51-6
(R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / -70 °C

1.2: 2 h / -70 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -70 °C

2.2: 1 h / -70 °C

3.1: hydrogen / Wilkinson's catalyst / benzene / 8 h / 20 °C

4.1: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water / 72 h / 20 °C

With n-butyllithium; hydrogen; hydroxylamine; lithium hexamethyldisilazane; Wilkinson's catalyst; potassium cyanide; In tetrahydrofuran; methanol; hexane; water; benzene;

Reference yield:

: 261951-70-6
4-(bromomethyl)-1-fluoro-2-methylbenzene

: 1043450-51-6
(R)-6-(4-Fluoro-3-methylbenzyloxy)-2-(4-fluoro-3-methylphenoxy)-N-hydroxyhexanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 8 h / 20 °C

2.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 2.5 h / 0 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -70 °C

3.2: 1 h / -70 °C

4.1: hydrogen / Wilkinson's catalyst / benzene / 8 h / 20 °C

5.1: hydroxylamine / potassium cyanide / tetrahydrofuran; methanol; water / 72 h / 20 °C

With 1H-imidazole; hydrogen; hydroxylamine; iodine; sodium hydride; triphenylphosphine; lithium hexamethyldisilazane; Wilkinson's catalyst; potassium cyanide; In tetrahydrofuran; methanol; dichloromethane; water; benzene;